2D motion graphics involve animating elements like typography and illustrations within a two-dimensional space, bringing static designs to life with movement and visual interest to convey information or tell a story. In contrast, 3D motion graphics create depth and realism using three-dimensional objects and environments, allowing for more complex and immersive animations. Both 2D and 3D motion graphics are extensively used across various mediums, such as advertising, film, and digital media, to captivate audiences and enhance visual storytelling.